Development of clinical signs and occurrence of feline corona virus antigen in naturally infected barrier reared cats and their offspring.
Identifieur interne : 001315 ( Main/Exploration ); précédent : 001314; suivant : 001316Development of clinical signs and occurrence of feline corona virus antigen in naturally infected barrier reared cats and their offspring.
Auteurs : K. Hök [Suède]Source :
- Acta veterinaria Scandinavica [ 0044-605X ] ; 1993.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés (microbiologie), Antigènes viraux (analyse), Chats, Conjonctivite (microbiologie), Conjonctivite (médecine vétérinaire), Coronavirus (immunologie), Coronavirus (isolement et purification), Femelle, Grossesse, Infections de l'appareil respiratoire (microbiologie), Infections de l'appareil respiratoire (médecine vétérinaire), Membrane nictitante (microbiologie), Mâle, Péritonite infectieuse féline (immunologie), Péritonite infectieuse féline (transmission).
- MESH :
- analyse : Antigènes viraux.
- immunologie : Coronavirus, Péritonite infectieuse féline.
- isolement et purification : Coronavirus.
- microbiologie : Animaux nouveau-nés, Conjonctivite, Infections de l'appareil respiratoire, Membrane nictitante.
- médecine vétérinaire : Conjonctivite, Infections de l'appareil respiratoire.
- transmission : Animaux, Chats, Femelle, Grossesse, Mâle, Péritonite infectieuse féline.
English descriptors
- KwdEn :
- Animals, Animals, Newborn (microbiology), Antigens, Viral (analysis), Cats, Conjunctivitis (microbiology), Conjunctivitis (veterinary), Coronavirus (immunology), Coronavirus (isolation & purification), Feline Infectious Peritonitis (immunology), Feline Infectious Peritonitis (transmission), Female, Male, Nictitating Membrane (microbiology), Pregnancy, Respiratory Tract Infections (microbiology), Respiratory Tract Infections (veterinary).
- MESH :
- chemical , analysis : Antigens, Viral.
- immunology : Coronavirus, Feline Infectious Peritonitis.
- isolation & purification : Coronavirus.
- microbiology : Animals, Newborn, Conjunctivitis, Nictitating Membrane, Respiratory Tract Infections.
- transmission : Feline Infectious Peritonitis.
- veterinary : Conjunctivitis, Respiratory Tract Infections.
- Animals, Cats, Female, Male, Pregnancy.
Abstract
The onset and pattern of the clinical signs of feline corona virus (FCoV) infection in cats were studied in a setting behind an isolation barrier. Two FCoV-seropositive cats were the source of the infection, and 3 barrier reared cats - initially FCoV-seronegative - were the recipients. The first clinical sign in the recipients appeared 11 days after contact with the source of infection. After 2 years 1 male and 1 female of the recipients started to breed. Their offspring developed clinical signs of disease at an age of 4-5 weeks. A pattern of recurring upper respiratory tract signs and conjunctivitis at intervals of about 4 months was observed in both the recipients and their offspring, while CNS dependent signs and wasting remained or got worse, once developed. Once demonstrated, FCoV antigen persisted in membrana nictitans throughout the investigation, and was found in all cats but 4 (90%). The offspring died during 2 periods, around the first week of life (9/37), and at 3-5 months of age (5/25). For comparison 3 offspring were euthanized at an age of 1 day and 16 offspring at an age of 3-6 months. FCoV antigen was demonstrated in all organs investigated (100%) from offspring dying during the first period, and in 97% from those dying during the second period. For the offspring euthanized during the same 2 periods the corresponding findings were 95% and 85%. Offspring euthanized between 9 and 17 months (4 kittens) had antigen in 67% of all investigated organs. The incidence of FCoV antigen in almost every organ in the investigated newborn kittens suggests an intrauterine infection. The demonstration of FCoV antigen in all euthanised cats, suggests a persistent infection. Virus was cultivated from membrana nictitans, that was FCoV antigen positive in the M3 test.
PubMed: 8147286
Affiliations:
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Le document en format XML
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Hök</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Microbial Ecology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Microbial Ecology, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><series><title level="j">Acta veterinaria Scandinavica</title><idno type="ISSN">0044-605X</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn (microbiology)</term><term>Antigens, Viral (analysis)</term><term>Cats</term><term>Conjunctivitis (microbiology)</term><term>Conjunctivitis (veterinary)</term><term>Coronavirus (immunology)</term><term>Coronavirus (isolation & purification)</term><term>Feline Infectious Peritonitis (immunology)</term><term>Feline Infectious Peritonitis (transmission)</term><term>Female</term><term>Male</term><term>Nictitating Membrane (microbiology)</term><term>Pregnancy</term><term>Respiratory Tract Infections (microbiology)</term><term>Respiratory Tract Infections (veterinary)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés (microbiologie)</term><term>Antigènes viraux (analyse)</term><term>Chats</term><term>Conjonctivite (microbiologie)</term><term>Conjonctivite (médecine vétérinaire)</term><term>Coronavirus (immunologie)</term><term>Coronavirus (isolement et purification)</term><term>Femelle</term><term>Grossesse</term><term>Infections de l'appareil respiratoire (microbiologie)</term><term>Infections de l'appareil respiratoire (médecine vétérinaire)</term><term>Membrane nictitante (microbiologie)</term><term>Mâle</term><term>Péritonite infectieuse féline (immunologie)</term><term>Péritonite infectieuse féline (transmission)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term><term>Péritonite infectieuse féline</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>Feline Infectious Peritonitis</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Animaux nouveau-nés</term><term>Conjonctivite</term><term>Infections de l'appareil respiratoire</term><term>Membrane nictitante</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Animals, Newborn</term><term>Conjunctivitis</term><term>Nictitating Membrane</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Conjonctivite</term><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Feline Infectious Peritonitis</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Conjunctivitis</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cats</term><term>Female</term><term>Male</term><term>Pregnancy</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Animaux</term><term>Chats</term><term>Femelle</term><term>Grossesse</term><term>Mâle</term><term>Péritonite infectieuse féline</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The onset and pattern of the clinical signs of feline corona virus (FCoV) infection in cats were studied in a setting behind an isolation barrier. Two FCoV-seropositive cats were the source of the infection, and 3 barrier reared cats - initially FCoV-seronegative - were the recipients. The first clinical sign in the recipients appeared 11 days after contact with the source of infection. After 2 years 1 male and 1 female of the recipients started to breed. Their offspring developed clinical signs of disease at an age of 4-5 weeks. A pattern of recurring upper respiratory tract signs and conjunctivitis at intervals of about 4 months was observed in both the recipients and their offspring, while CNS dependent signs and wasting remained or got worse, once developed. Once demonstrated, FCoV antigen persisted in membrana nictitans throughout the investigation, and was found in all cats but 4 (90%). The offspring died during 2 periods, around the first week of life (9/37), and at 3-5 months of age (5/25). For comparison 3 offspring were euthanized at an age of 1 day and 16 offspring at an age of 3-6 months. FCoV antigen was demonstrated in all organs investigated (100%) from offspring dying during the first period, and in 97% from those dying during the second period. For the offspring euthanized during the same 2 periods the corresponding findings were 95% and 85%. Offspring euthanized between 9 and 17 months (4 kittens) had antigen in 67% of all investigated organs. The incidence of FCoV antigen in almost every organ in the investigated newborn kittens suggests an intrauterine infection. The demonstration of FCoV antigen in all euthanised cats, suggests a persistent infection. Virus was cultivated from membrana nictitans, that was FCoV antigen positive in the M3 test.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Hok, K" sort="Hok, K" uniqKey="Hok K" first="K" last="Hök">K. Hök</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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